Finding Motifs with Insufficient Number of Strong Binding Sites
نویسندگان
چکیده
منابع مشابه
Finding Motifs with Insufficient Number of Strong Binding Sites
A molecule called transcription factor usually binds to a set of promoter sequences of coexpressed genes. As a result, these promoter sequences contain some short substrings, or binding sites, with similar patterns. The motif discovering problem is to find these similar patterns and motifs in a set of sequences. Most existing algorithms find the motifs based on strong-signal sequences only (i.e...
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MOTIVATION Finding common patterns, motifs, from a set of promoter regions of coregulated genes is an important problem in molecular biology. Most existing motif-finding algorithms consider a set of sequences bound by the transcription factor as the only input. However, we can get better results by considering sequences that are not bound by the transcription factor as an additional input. RE...
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The identification of over-represented but imperfectly conserved motifs in genomic DNA is a problem with important biological applications, such as the discovery of regulatory elements that determine the timing, location, and level of gene transcription. Experimental techniques such as ChIP-chip and geneexpression microarrays can identify sets of genomic regions that are likely to be enriched f...
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ژورنال
عنوان ژورنال: Journal of Computational Biology
سال: 2005
ISSN: 1066-5277,1557-8666
DOI: 10.1089/cmb.2005.12.686