Fine scale differences within the vagal neural crest for enteric nervous system formation
نویسندگان
چکیده
منابع مشابه
Neural crest regionalisation for enteric nervous system formation: implications for Hirschsprung's disease and stem cell therapy.
Midbrain, hindbrain and vagal neural crest (NC) produced abundant enteric nervous system (ENS) in co-grafted aneural hindgut and midgut, using chick-quail chorio-allantoic membrane grafts, forming complete myenteric and submucosal plexuses. This ability dropped suddenly in cervical and thoracic NC levels, furnishing an incomplete ENS in one or both plexuses. Typically, one plexus was favoured o...
متن کاملMigration of neural crest-derived enteric nervous system precursor cells to and within the gastrointestinal tract.
The enteric nervous system, the intrinsic innervation of the gastrointestinal tract, consists of large numbers of phenotypically diverse neurons and glial cells, arranged in complex interconnecting plexuses situated between the smooth muscle layers of the gut wall. Recently, the enteric nervous system has attracted much attention from developmental biologists whose efforts have focused on analy...
متن کاملVagal input to the enteric nervous system.
Background The enteric nervous system (ENS) of the gastrointestinal tract has traditionally been viewed as a system of ganglia that operates largely independently of the brain and spinal cord. Because of this postulated autonomy, the ENS has even been characterised as the “little brain” or the “second brain.” Recent neural tracing studies, however, challenge this canon of ENS autonomy. The view...
متن کاملBMP signaling is necessary for neural crest cell migration and ganglion formation in the enteric nervous system
The enteric nervous system (ENS) is derived from neural crest cells that migrate along the gastrointestinal tract to form a network of neurons and glia that are essential for regulating intestinal motility. Despite the number of genes known to play essential roles in ENS development, the molecular etiology of congenital disorders affecting this process remains largely unknown. To determine the ...
متن کاملMeis3 is required for neural crest invasion of the gut during zebrafish enteric nervous system development
During development, vagal neural crest cells fated to contribute to the enteric nervous system migrate ventrally away from the neural tube toward and along the primitive gut. The molecular mechanisms that regulate their early migration en route to and entry into the gut remain elusive. Here we show that the transcription factor meis3 is expressed along vagal neural crest pathways. Meis3 loss of...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2019
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2018.11.007