Fine structure of translocation breakpoints in leukemic blasts with chromosomal translocation t(4;11): the DNA damage-repair model of translocation
نویسندگان
چکیده
منابع مشابه
Clustering of Translocation Breakpoints
Translocation, a physical movement of genetic material from one chromosome to another, can aberrantly juxtapose portions of two cellular genes. This type of fusion may disrupt cellular function by producing novel, biologically-active fused genes, or by the activation of normally quiescent growth-associated genes. Either of these mechanisms provides a putative oncogenic stimulus and, indeed, sev...
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Introduction: Intellectual disability or intellectual retardation is a condition in which total mental functioning is distinctively below average and there are disabilities in adaptive behaviors during growth. According to the definition of American Mental Disability Community in 1992 a person is considered intellectually disabled if he or she has an IQ (intelligence quotient) of less than 70...
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Triploidy is a lethal chromosomal abnormality. Foetuses with triploid condition have a tendency to die in early conception and very few survive to term. In this study, we report the prenatal diagnosis of fetal triploidy with unexpected chromosomal translocation. A 27 years old women was referred to our clinical cytogenetic department due to history of previous conceptus with intrauterine growth...
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Background: Most of our current understanding of the biological effects of exposure to ionising radiation is based on conventional cytogenetic techniques, which enable us to determine the relationship between chromosomal aberration and dose received by radiation workers. However, conventional techniques have numerous limitations and chromosomal aberrations can be easily missed. Since FISH plays...
متن کاملInositol phospholipids: Translocation, translocation, translocation …
The pleckstrin homology (PH) domains of a number of proteins have been found to interact in vitro with inositol phospholipids; recent experiments show that these interactions may be important in directing protein translocation to specific parts of the cell following stimulus-induced lipid breakdown or synthesis.
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ژورنال
عنوان ژورنال: Oncogene
سال: 1998
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1202229