Fixed-Dose Combination (FDC) Formulation of Quinine Sulphate-Doxycycline (Qidox) for Malaria Therapy

Effectiveness of RHZE-FDC (fixed-dose combination) compared to RH-FDC + Z for tuberculosis treatment in Brazil: a cohort study

BACKGROUND In 2009, Brazil was the sole high-burden country to use three drugs [rifampin (R), isoniazid (H) and pyrazinamide (Z)] as the standard treatment for sensitive tuberculosis, with RH in fixed-dose combination (FDC). In December 2009, the country has adopted the FDC four-drug regimen including ethambutol (E). The rationale was the expectation to reduce default and resistance rates, by i...

The Treatment of Malaria by Quinine in Combination with Magnesium Sulphate and Alkali

Fixed-dose combination Therapy in Hypertension: Focus on Fixed-dose combination of Amlodipine and Valsartan (exforge®)

Hypertension is the leading cause of disability and cardiovascular mortality world-wide. Approximately one-third of the US adult population and over a billion people world-wide have hypertension. Despite increased awareness of hypertension and availability of many effective antihypertensive agents, only one third of patients achieve their target blood pressure (BP). All expert panels now recomm...

Effect of fixed-dose combination (FDC) drugs on development of clinical antimicrobial resistance: a review paper

The emergence of previously unreported infectious diseases, the re‐emergence of infectious disease thought to have been on the way to elimination, and the rapid evolution of infectious pathogens exhibiting antimicrobial resistance (“AMR”) and in particular, multiple‐drug resistance (“MDR”) have created a major clinical and public health threat of global dimensions. The idea that AMR can be del...

Effect of fixed-dose combination (FDC) medications on adherence and treatment outcomes

Low adherence to prescribed self‐administered medication is well documented and particularly problematic in the treatment of chronic or asymptomatic conditions1 2. Even in affluent countries with well developed health care infrastructure adherence to long‐term therapy is estimated to average only 50%3. The implications of poor adherence are substantial at both the individual and population lev...