Fixed-dose combination inhalers compared to long-acting bronchodilators for COPD: a network meta-analysis
نویسندگان
چکیده
منابع مشابه
Comparative efficacy of long-acting bronchodilators for COPD - a network meta-analysis
BACKGROUND Clinicians are faced with an increasingly difficult choice regarding the optimal bronchodilator for patients with chronic obstructive pulmonary disease (COPD) given the number of new treatments. The objective of this study is to evaluate the comparative efficacy of indacaterol 75/150/300 μg once daily (OD), glycopyrronium bromide 50 μg OD, tiotropium bromide 18 μg/5 μg OD, salmeterol...
متن کاملLong-acting bronchodilators improve exercise capacity in COPD patients: a systematic review and meta-analysis
Background: We carried out a systematic review and meta-analysis with the aim to evaluate the efficacy of longacting bronchodilators on exercise capacity in COPD patients. Methods: The endpoints were the efficacy of long-acting bronchodilators (altogether, and by single classes) vs. placebo in modifying endurance time (ET), inspiratory capacity (IC) and dyspnea during exercise, taking into cons...
متن کاملPHARMAC responds on long-acting inhalers for COPD.
• The prevalence of COPD—and numbers of patients eligible for tiotropium treatment—can be difficult to quantify, with wide-ranging estimates according to the definitions of COPD used. A possible range is between 65,000 and 85,000 patients with COPD, with perhaps one-quarter having severe COPD at the level of FEV1 < 40% predicted. Hence there may be 15,000 to 21,000 patients with severe COPD (FE...
متن کاملEfficacy and safety of long-acting β-agonist/long-acting muscarinic antagonist combinations in COPD: a network meta-analysis.
BACKGROUND The place of long-acting β agonist/long-acting muscarinic antagonist (LABA/LAMA) combinations in stable patients with COPD is not well defined. The purpose of this study was to systematically review the efficacy and safety of LABA/LAMA combinations. METHODS Several databases and manufacturers' websites were searched for relevant clinical trials. Randomised control trials, at least ...
متن کاملPredicting treatable traits for long-acting bronchodilators in patients with stable COPD
Purpose There is currently no measure to predict a treatability of long-acting β-2 agonist (LABA) or long-acting muscarinic antagonist (LAMA) in patients with chronic obstructive pulmonary disease (COPD). We aimed to build prediction models for the treatment response to these bronchodilators, in order to determine the most responsive medication for patients with COPD. Methods We performed a p...
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ژورنال
عنوان ژورنال: Cochrane Database of Systematic Reviews
سال: 2017
ISSN: 1465-1858
DOI: 10.1002/14651858.cd012620