Fixed dose drug combinations (FDCs): rational or irrational: a view point
نویسندگان
چکیده
منابع مشابه
Irrational fixed dose combinations in Nepal: need for intervention.
A large proportion of drugs available are of little importance in terms of fulfilling primary healthcare needs. Combination drugs increase the risk of side effects, lead to an ineffective dosage and liability to abuse and may also needlessly increase the cost. Drug combinations make it more difficult to find the causative agent responsible for the adverse reactions. In many cases their stabilit...
متن کاملCost analysis of HIV treatment and drug-related adverse events when fixed-dose combinations of antiretrovirals (FDCs) were stopped, versus continuation with FDCs
BACKGROUND The lower sales price of generic lamivudine has caused healthcare administrators to consider abolishing fixed-dose antiretroviral combinations (FDCs) that contain lamivudine and emtricitabine. The alternative is to administer the individual components of the FDCs separately, thus incorporating the new generic lamivudine medication. METHODS The Balearic Islands Health Service ordere...
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Improvised formulation technology In the early 1990s, FDCs of antitubercular drugs were not advocated because of their relatively poor bioavailability and short shelf life. [3] With the present improved formulation technologies, the currently available FDCs are bioequivalent to single drug reference products. Moreover, the stability of these FDCs even after six months in tropical countries is w...
متن کاملFixed dose drug combinations: Issues and challenges in India
Medicines are an integral part of healthcare. More than one drug is frequently used for treatment of either single ailment or multiple comorbid conditions. Sometimes, two or more drugs are combined in a fixed ratio into a single dosage form, which is termed as fixed dose combinations (FDCs). The FDCs are justified when they demonstrate clear benefits in terms of (a) potentiating the therapeutic...
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Sir, The Standing Parliamentary Committee that investigated the functioning of Central Drugs Standard Control Organization (CDSCO) noted that the regulatory body “had skewed priorities, according primacy to the propagation and facilitation of the drugs industry, due to which, the interest of the biggest stakeholder, i.e. the consumer has never been ensured.”[1] The report discussed CDSCO’s inab...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2008
ISSN: 0306-5251,1365-2125
DOI: 10.1111/j.1365-2125.2007.03089.x