Fixing a feedback loop in fibrosis
نویسندگان
چکیده
منابع مشابه
Activation of TGF-β1-CD147 positive feedback loop in hepatic stellate cells promotes liver fibrosis
Activation of hepatic stellate cells (HSCs) by transforming growth factor-β1 (TGF-β1) initiates HBV-associated fibrogenesis. The mechanism of TGF-β1 modulating HSC activation is not fully uncovered. We hypothesized a positive feedback signaling loop of TGF-β1-CD147 promoting liver fibrogenesis by activation of HSCs. Human HSC cell line LX-2 and spontaneous liver fibrosis model derived from HBV ...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2015
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd4559