Fluorescence of experimental atheromatous plaques with hematoporphyrin derivative.

Ruptured Atheromatous Plaques

Although early occlusion of saphenous vein coronary artery bypass grafts is usually thrombotic, late occlusion is most often a result of progressive intimal fibromuscular proliferation or atheroma formation in the implanted vein. We describe another mechanism of late graft occlusion: atheromatous plaque rupture with superimposed occlusive thrombosis. Four men, ages 48-67 years underwent repeat ...

Laser-induced Fluorescence Studies of Hematoporphyrin Derivative (hpd) In Normal and Tumor-tissue of Rat

Fluorescence studies of hematoporphyrin derivative in normal and malignant rat tissue.

Laser-induced fluorescence in rat tissue was studied during the uptake and clearing period of i.v.-injected hematoporphyrin derivative. A malignant rat tumor and normal tissue of 20 different kinds from the tumor-bearing animals were investigated. A pulsed nitrogen laser (337 nm) was used in conjunction with an optical multichannel analyzer system, in which the whole fluorescence light distribu...

Diagnosis of model choroidal malignant melanoma by hematoporphyrin derivative fluorescence in rabbits.

A nonsurgical experimental system for detection of malignant tissue in the posterior ocular segment has been developed. A choroidal amelanotic malignant melanoma in rabbits served as a tumor model. Fluorescence of an hematoporphyrin derivative which is concentrated by malignant tissue was observed and measured simultaneously, using a modified binocular indirect ophthalmoscope. Clinical evaluati...

Pharmacological modulation of photodynamic therapy with hematoporphyrin derivative and light.

The interactions between photodynamic therapy (PDT) with hemotoporphyrin derivative (HPD) and treatment with cytotoxic drugs have been examined using both an in vitro tissue culture assay and an in vivo transplantable mouse tumor assay. Adriamycin (0.5-4.0 mg/kg) administered with HPD and at the time of irradiation potentiated the photodynamic effect, doubling the duration of tumor control. Adr...