Force-Induced Rupture of a DNA Duplex: From Fundamentals to Force Sensors
نویسندگان
چکیده
منابع مشابه
Force-induced melting of DNA—evidence for peeling and internal melting from force spectra on short synthetic duplex sequences
Overstretching of DNA occurs at about 60-70 pN when a torsionally unconstrained double-stranded DNA molecule is stretched by its ends. During the transition, the contour length increases by up to 70% without complete strand dissociation. Three mechanisms are thought to be involved: force-induced melting into single-stranded DNA where either one or both strands carry the tension, or a B-to-S tra...
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ژورنال
عنوان ژورنال: ACS Nano
سال: 2015
ISSN: 1936-0851,1936-086X
DOI: 10.1021/acsnano.5b04726