Force spectroscopy of complex biopolymers with heterogeneous elasticity
نویسندگان
چکیده
منابع مشابه
Force spectroscopy of complex biopolymers with heterogeneous elasticity.
Cellular biopolymers can exhibit significant compositional heterogeneities as a result of the non-uniform binding of associated proteins, the formation of microstructural defects during filament assembly, or the imperfect bundling of filaments into composite structures of variable diameter. These can lead to significant variations in the local mechanical properties of biopolymers along their le...
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Networks of the biopolymer actin, cross-linked by the compliant protein filamin, form soft gels. They can, however, withstand large shear stresses due to their pronounced nonlinear elastic behavior. The nonlinear elasticity can be controlled by varying the number of cross-links per actin filament. We propose and test a model of rigid filaments decorated by multiple flexible linkers that is in q...
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ژورنال
عنوان ژورنال: Soft Matter
سال: 2013
ISSN: 1744-683X,1744-6848
DOI: 10.1039/c2sm27218k