Formulation development and evaluation of gastroretentive floating drug delivery system using natural polymer.
نویسندگان
چکیده
منابع مشابه
Formulation Development and Evaluation of Gastro Retentive Floating Drug Delivery System for Novel Fluoroquinolone using Natural and Semisynthetic Polymers
The purpose of present research work is to develop gastro retentive formulation for Moxifloxacin using various release retardants. Moxifloxacin, novel synthetic fluoro quinolone, antibacterial agent. Floating tablets of Moxifloxacin. HCl were prepared using variable amounts of HPMCK4M, HPMCK15M and HPMCK100M with effervescent mixtures by direct compression technique. Totally 9 formulations were...
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The present investigation describes the design and evaluation of monolithic gastro retentive dosage forms of diltiazem. Hydrophilic cellulose derivatives, Sodium alginate, Sodium carboxy methyl cellulose, Polyox, Methocel K100M in combination with Methocel E6LV are used as the rate controlling polymers. Sodium bicarbonate was incorporated as gas generating agent. Tablets were prepared by employ...
متن کاملFormulation and evaluation of multiple tablets as a biphasic gastroretentive floating drug delivery system for fenoverine.
A biphasic gastroretentive drug delivery system of fenoverine was developed to maintain constant plasma concentration. The delivery system consisted of a loading-dose tablet and a floating multiple matrix tablet prepared by the direct compression process. The drug release from biphasic GRDDS in 0.1 mol L(-1) HCl and SGF (enzyme free) was sustained over 12 h with buoyant properties. Stability st...
متن کاملFormulation Development and Evaluation of Hydrogel Based Gastroretentive Drug Delivery System of Antihypertensive Drug
Site specific drug delivery has become the important aspect of research. In present study focused has been made to formulate gastroretentive drug delivery (GRDDS) of drugs having narrow absorption window or having good absorption at proximal part of gastrointestinal tract (GIT) to deliver at stomach site. Hydrogel based gastroretentive formulation of ramipril were prepared by gas blowing techni...
متن کاملDevelopment and Evaluation of Gastroretentive Floating Drug Delivery System of Atenolol
Atenolol, an antihypertensive drug, has poor bioavailability (40-50%) and has has low elimination half life(6 hr). Atenolol is mainly absorbed in the stomach. The floating tablets of atenolol were prepared to increase the gastric retention, extend the drug release and to improve the bioavailability of the drug. The floating tablets were formulated using HPMC 100 cps, sodium alginate, carbopol 9...
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ژورنال
عنوان ژورنال: Journal of Current Pharma Research
سال: 2018
ISSN: 2230-7834,2230-7842
DOI: 10.33786/jcpr.2018.v08i03.005