Fosfomycin Causes Transient Lysis in Escherichia coli Strains Carrying Fosfomycin-resistance Plasmids
نویسندگان
چکیده
منابع مشابه
Fosfomycin resistance plasmids do not affect fosfomycin transport into Escherichia coli.
Escherichia coli cells carrying fosfomycin resistance plasmids were able to take up fosfomycin from the medium to the same extent as plasmid-free bacteria. The antibiotic entered the plasmid-harboring cells by means of the glpT and uhp transport systems, as is the case with susceptible bacteria. Active fosfomycin could be detected in soluble extracts of cells which had previously been incubated...
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The target enzyme for fosfomycin antibiotic action, enolpyruvyl transferase, was synthesized in similar amounts and with similar kinetic and inhibition constants for phosphoenolpyruvate and fosfomycin, respectively, by an Escherichia coli strain containing the fosfomycin resistance plasmid pOU900 and by plasmid-free strains. Neither phosphoenolpyruvate level nor murein synthesis was altered by ...
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Fosfomycin resistance in Escherichia coli is rare in the United States. An extended-spectrum β-lactamase-producing E. coli clinical strain identified in Pennsylvania, USA, showed high-level fosfomycin resistance caused by the fosA3 gene. The IncFII plasmid carrying this gene had a structure similar to those found in China, where fosfomycin resistance is commonly described.
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Fosfomycin, [L-(cis)-1, 2-epoxypropyl phosphonic acid] (FOM), a broad spectrum antibiotic produced by some strains of Streptomyces species1), acts as a phosphoenolpyruvate analog and irreversibly inhibits phosphoenolpyruvate UDP-N-acetylglucosamine (UDPG1cNAc)-3-O-enolpyruvyl transferase, an enzyme which catalyzes the first step of peptidoglycan biosynthesis2). FOM enters susceptible bacteria b...
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Introduction: Urinary tract infection is a common nosocomial infection that has recently become difficult to treat because of the increased emergence of multi-drug resistant strains. This study aims to determine the minimum inhibitory concentration, and molecular pattern of resistance to fosfomycin in Escherichia coli isolates originated from patients hospitalized with urinary tract infection i...
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ژورنال
عنوان ژورنال: Microbiology
سال: 1985
ISSN: 1350-0872,1465-2080
DOI: 10.1099/00221287-131-12-3255