FOXA1 upregulation promotes enhancer and transcriptional reprogramming in endocrine-resistant breast cancer
نویسندگان
چکیده
منابع مشابه
LRH-1 governs vital transcriptional programs in endocrine-sensitive and -resistant breast cancer cells.
Tumor characteristics are decisive in the determination of treatment strategy for patients with breast cancer. Patients with estrogen receptor α (ERα)-positive breast cancer can benefit from long-term hormonal treatment. Nonetheless, the majority of patients will develop resistance to these therapies. Here, we investigated the role of the nuclear receptor liver receptor homolog-1 (LRH-1, NR5A2)...
متن کاملFOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer.
Forkhead box protein A1 (FOXA1) is a pioneer factor of estrogen receptor α (ER)-chromatin binding and function, yet its aberration in endocrine-resistant (Endo-R) breast cancer is unknown. Here, we report preclinical evidence for a role of FOXA1 in Endo-R breast cancer as well as evidence for its clinical significance. FOXA1 is gene-amplified and/or overexpressed in Endo-R derivatives of severa...
متن کاملDelineation of a FOXA1/ERα/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer.
UNLABELLED Tamoxifen, a selective estrogen receptor (ER) modulator (SERM), remains a frontline clinical therapy for patients with ERα-positive breast cancer. However, the relatively rapid development of resistance to this drug in the metastatic setting remains an impediment to a durable response. Although drug resistance likely arises by many different mechanisms, the consensus is that most of ...
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objective: during the past decade, the importance of biomarker discovery has been highlighted in many aspects of cancer research. biomarkers may have a role in early detection of cancer, prognosis and survival evaluation as well as drug response. cancer-testis antigens (ctas) have gained attention as cancer biomarkers because of their expression in a wide variety of tumors and restricted expres...
متن کاملNa+/K+ ATPase activity promotes invasion of endocrine resistant breast cancer cells
BACKGROUND The Na+/K+-ATPase (NKP) is an important ion transporter also involved in signal transduction. Its expression profile is altered in various tumours including that of the breast. We studied the effect of inhibiting NKP activity in non-tumorigenic breast cell line and in estrogen receptor positive and negative breast cancer cells. METHODS Expression and localization of NKP and downstr...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2019
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1911584116