Fractionation of Cigarette Smoke Condensate for Biological Testing: Concentration of Polynuclear Aromatic Hydrocarbon and Weak-Acid Fractions
نویسندگان
چکیده
منابع مشابه
Large-Scale Fractionation of Cigarette Smoke Condensate for Chemical and Biologic Investigations1
Most of the tumorigenicity of CSC for animals can be con centrated in the neutral and acidic fractions. In an early study (19), roughly quantitative results showed that, although the major tumor-initiating activity was concentrated in the carbon tetrachloride eluate from silicic acid chromatography of the neutrals, some activity was found in the hexane eluate from this column, and additional ac...
متن کاملLarge-scale fractionation of cigarette smoke condensate for chemical and biologic investigations.
Most of the tumorigenicity of CSC for animals can be con centrated in the neutral and acidic fractions. In an early study (19), roughly quantitative results showed that, although the major tumor-initiating activity was concentrated in the carbon tetrachloride eluate from silicic acid chromatography of the neutrals, some activity was found in the hexane eluate from this column, and additional ac...
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The results of bioassays of fractions of cigarette smoke con densate (CSC) using mice previously treated with 7,12-dimeth ylbenz[a@ anthracene (DMBA) are reported. The assay was designed to detect complete carcinogens as well as fractions possessing only tumor-promoting activity. The results showed that the weak acid (phenol) fraction and two neutral fractions exhibited statistically significan...
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Although products of pyrolysis are often cytotoxic and mutagenic, the relationship between the type of material pyrolysed and the toxicity of the resulting pyrolysis products is poorly understood. The objective of this study was to evaluate and compare the cytotoxicity and mutagenicity of several types of common pyrolysis products. The cytotoxicity and mutagenicity of these products were assess...
متن کاملThe combined carcinogenic effect of cigarette smoke condensate and urethan.
The role of tobacco tar in the development of lung adenomas was investigated in A mice of both sexes given a single intraperitoneal threshold or subthreshold dose of ethyl carbamate. Incidence of lung tumors indicated a highly significant increase in response to urethan from subthreshold to D50. When additional groups of mice were given urethan and the oral area was painted 5 times weekly for 6...
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ژورنال
عنوان ژورنال: Beiträge zur Tabakforschung / Contributions to Tobacco Research
سال: 1975
ISSN: 1612-9237
DOI: 10.2478/cttr-2013-0368