Freeze-dried cake structural and physical heterogeneity in relation to freeze-drying cycle parameters
نویسندگان
چکیده
منابع مشابه
Sperm freeze-drying; effects on sperm parameters
Today, sperm cryopreservation is a routine practice in infertility clinics. One of the alternative methods to preserve sperm is freeze-drying. This process consists of three steps. The first step is sample freezing, during which the solvent is separated from the solvent. Water forms ice crystals and the solute is placed between the ice crystals. Freezing may be done in a separate device or in a...
متن کاملCirculating-Gas Freeze Drying
WAGMAN, JACK (U.S. Army Biological Laboratories, Frederick, Md.) AND EDWARD J. WENECK. Preservation of bacteria by circulating-gas freeze drying. Appl. Microbiol. 11:244-248. 1963.-Water-washed Serratia marcescens and Escherichia coli were freeze dried in a circulating-gas system at atmospheric pressure. This convective procedure resulted in a substantially higher survival of organisms than cou...
متن کاملFreeze-dried B.C.G.
Freeze-dried B.C.G. of British manufacture became available for experimental work in 1955. The main reason for introducing it was the need for a vaccine which would retain its potency under conditions of prolonged storage. On reconstitution for injection the vaccine should produce a uniform suspension with minimal clumping, resulting in a uniform viable bacterial count. These properties mean th...
متن کاملControlling the physical form of mannitol in freeze-dried systems.
A potential drawback with the use of mannitol as a bulking agent is its existence as mannitol hemihydrate (MHH; C₆H₁₄O₆·0.5H₂O) in the lyophile. Once formed during freeze-drying, MHH dehydration may require secondary drying under aggressive conditions which can be detrimental to the stability of thermolabile components. If MHH is retained in the lyophile, the water released by MHH dehydration d...
متن کاملComparative study of three drying methods: freeze, hot air- assisted freeze and infrared-assisted freeze modes
The dehydration tests were conducted at three drying methods to evaluate the drying curves and the energy uptake. Apple (Malus domestica L.) cubes were dried under different processing conditions applying freeze drying (FD), freeze drying assisted by hot air and freeze drying assisted by infrared radiation. Control samples were produced using regular freeze drying without the pre-drying. Hot ai...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2020
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2020.119891