Freeze-drying of ampicillin solid lipid nanoparticles using mannitol as cryoprotectant
نویسندگان
چکیده
منابع مشابه
Optimization of Freeze Drying Condition of Prednisoloneacetate Solid Lipid Nanparticles Using Box-behnken Design
INTRODUCTION Nanoparticulate carrier system was used to target, improve bioavailability, control the drug release and avoid the enzymatic degradation. Among the nanoparticulates i.e. SLNs are attractive and face the challenges of stability. The major obstacle with the SLNs was agglomeration in order to avoid this problem freeze drying was attempted. In this laboratory process which involves fre...
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Submit Manuscript | http://medcraveonline.com Abbreviations: SLN: Solid Lipid Nanoparticles; PQ-SLNs: PQLoaded Solid Lipid Nanoparticles; o/w: Oil-in-Water; SA: Stearic Acid; PVA: Polyvinyl Alcohol; EtOAc: Ethyl Acetate; w/o: Waterin-Oil; PDI: Poly Dispersity Index; DLS: Dynamic Light Scattering; FD: Freeze Drying; HEPES: N-2-Hydroxyethylpiperazine-N-2Ethanesulfonic Acid; NP: Nanoformulated Pri...
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Freeze-drying has been considered as a good technique to improve the long-term stability of colloidal nanoparticles. The poor stability in an aqueous medium of these systems forms a real barrier against the clinical use of nanoparticles. This article reviews the state of the art of freeze-drying nanoparticles. It discusses the most important parameters that influence the success of freeze-dryin...
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ژورنال
عنوان ژورنال: Brazilian Journal of Pharmaceutical Sciences
سال: 2015
ISSN: 1984-8250
DOI: 10.1590/s1984-82502015000400005