Frontiers in Nephrology: Targeting Inflammation Using Novel Nitric Oxide Donors
نویسندگان
چکیده
منابع مشابه
Frontiers in nephrology: targeting inflammation using novel nitric oxide donors.
Chimeric molecules are single-chemical entities that possess at least two separate functions. In the design of new chimeric medicines, the two biologic actions are often designed to be synergistic and, thereby, complement each other in activating a specific target, such as a gene, a receptor, or an enzyme. In most chimeric molecules, one functionality is designed to provide a high affinity to a...
متن کاملNitric oxide donors: novel cancer therapeutics (review).
The development of cancer cell resistance to various cytotoxic stimuli continues to be a major challenge in oncology and novel therapeutic approaches are urgently needed. Nitric oxide (NO) is emerging as a potential anti-oncogenic agent to overcome tumor cell resistance to conventional therapeutic agents. NO is a ubiquitous, water-soluble, free radical gas that exerts a wide range of biological...
متن کاملFrontiers in nephrology: tolerance.
The field of transplantation has come a long way since the first successful kidney transplant performed by Murray and colleagues in 1954. Kidney, heart, lung, and liver transplantation, among other organs, is now routine, and short-term (1 yr) outcomes have steadily improved to rates of 90 to 95% graft survival (http://www.unos.org). Despite these successes, the major shortfall of our current t...
متن کاملNitric oxide. II. Nitric oxide protects in intestinal inflammation.
This article examines the evidence for nitric oxide (NO) as a protective agent in splanchnic ischemia-reperfusion and other forms of acute intestinal inflammation. Four major points emerge from this body of data. First, acute intestinal inflammation results in an early (i.e., <5 min) and severe decrease in endothelium-derived NO. Thus the early trigger event in this condition is a functional lo...
متن کاملThe Role of Nitric Oxide Donors in Wound Healing in Diabetes Mellitus
Introduction: Diabetic foot ulcer is a serious complication of diabetes mellitus; it consists of lesions in the deep tissues associated with neurological disorders and peripheral vascular disease in the lower limbs. Delayed wound healing in diabetes leads to long-term hospitalization and even amputation of distal organs. Diabetes mellitus is associated with decreased nitric oxide bioavailabilit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2007
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2007030321