Frontispiece: Empowering Synthesis of Complex Natural Products
نویسندگان
چکیده
منابع مشابه
Natural Products Synthesis
Rhizopodin (1, Scheme 1) is an architecturally unique polyketide macrolide that was originally isolated from the myxobacterium Myxococcus stipitatus by the groups of Hçfle and Reichenbach. It shows potent antifungal and antiproliferative cytotoxicity against a range of tumor cell lines with IC50 values in the low nanomolar range. [1] On a molecular level, 1 disrupts the cytoskeleton of actin by...
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An overview of the synthesis of the fungal metabolites (+)-dermolactone, (-)- semixanthomegnin, (+)- and (-)-mellein, (-)-ochratoxin alpha, (-)-(1R,3S)-thysanone, the enantiopure ventiloquinones L, E and G, and 8-desmethyleleutherin from a common chiral intermediate, is presented. Further methodology leading potentially toward extended quinones such as (3S,3'S)-xylindein is also outlined.
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As a continuation of the first two Thematic Series in the Beilstein Journal of Organic Chemistry on natural products in 2011 and 2013 [1,2], it is my pleasure to present the third issue on this topic. Natural products continue to be an inspiring field of research and an important source of potent biologically active compounds. This was recently highlighted by the fact that last year’s Nobel Pri...
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ژورنال
عنوان ژورنال: Chemistry – A European Journal
سال: 2019
ISSN: 0947-6539,1521-3765
DOI: 10.1002/chem.201985862