Fructose-1,6-diphosphate attenuates prostaglandin E2production and cyclo-oxygenase-2 expression in UVB-irradiated HaCaT keratinocytes

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Fructose-1,6-diphosphate attenuates prostaglandin E2 production and cyclo-oxygenase-2 expression in UVB-irradiated HaCaT keratinocytes.

1. Fructose-1,6-diphosphate (FDP), a glycolytic metabolite, is reported to ameliorate inflammation and inhibit the nitric oxide production in murine macrophages stimulated with endotoxin. It is also reported that FDP has cytoprotective effects against hypoxia or ischaemia/reperfusion injury in brain and heart. However, underlying mechanisms of its various biological activities are not completel...

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ژورنال

عنوان ژورنال: British Journal of Pharmacology

سال: 2002

ISSN: 0007-1188

DOI: 10.1038/sj.bjp.0704896