Full correlation analysis of conformational protein dynamics
نویسندگان
چکیده
منابع مشابه
Full correlation analysis of conformational protein dynamics.
Correlated motions in biomolecules are often essential for their function, for example, allosteric signal transduction or mechanical/thermodynamic energy transport. Principal component analysis (PCA) is a widely used method to extract functionally relevant collective motions from a molecular dynamics (MD) trajectory. Being based on the covariance matrix, however, PCA detects only linear correla...
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ژورنال
عنوان ژورنال: Proteins: Structure, Function, and Bioinformatics
سال: 2007
ISSN: 0887-3585
DOI: 10.1002/prot.21618