Function of indoleamine 2,3-dioxygenase in corneal allograft rejection and prolongation of allograft survival by over-expression
نویسندگان
چکیده
منابع مشابه
Indoleamine 2,3-dioxygenase gene transfer prolongs cardiac allograft survival.
Cells that express indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme in the catabolism of tryptophan, suppress T cell responses and promote immunological tolerance. However, their role in solid organ transplantation is incompletely understood. We analyzed T cell responses to allogeneic dendritic cells (DCs) genetically modified to express the gene encoding IDO in vitro and IDO gene tr...
متن کاملCorneal allograft rejection.
The cornea is avascular, enjoys relative immune privilege, and immunosuppressive treatment can be directly applied: yet data from all available reports indicate that allogeneic rejection is the commonest cause of corneal graft failure. In Australia, 5 year actuarial corneal graft survival is 72%: irreversible rejection accounts for at least 33% of all graft failures.' Graft survival is much sho...
متن کاملCytokine expression during orthotopic corneal allograft rejection in mice.
PURPOSE The acquisition of cell-mediated immunity against donor antigens has been shown to be associated with rejection of orthotopic corneal allografts, but the mechanisms that cause corneal allograft destruction in grafted tissue remain obscure. To determine which T-cell subsets infiltrate graft tissue and cause graft rejection, cytokine expression was examined in corneal tissue after orthoto...
متن کاملEffect of Fas -670 A/G Gene Polymorphism on Corneal Allograft Endothelial Rejection
Background: Human cornea expresses functional Fas-ligand capable of killing Fas+ activated lymphocytes. Fas expression is partly regulated by -670 A/G polymorphism in the promoter region of Fas gene. Objective: The aim of the present study is to determine the association between Fas-670A/G polymorphism and survival of corneal transplantation. Methods: In 276 graft recipients who mainly underwen...
متن کاملCorrelation of Corneal Allograft Rejection with Tumor Necrosis Factors-Alpha Gene Polymorphism
Background: Correlations between bone marrow, heart, kidney, liver, skin and lung transplant rejection or survival with human cytokine gene polymorphisms have been described. There are also reports about the role of cytokines and Tumor Necrosis Factors-Alpha (TNF-α) on corneal transplant in animal models. Further studies are needed to clarify the role of cytokines in corneal allograft rejection...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2006
ISSN: 0014-2980,1521-4141
DOI: 10.1002/eji.200535238