Functional bottlenecks for generation of HIV-1 intersubtype Env recombinants
نویسندگان
چکیده
منابع مشابه
On-going generation of multiple forms of HIV-1 intersubtype recombinants in the Yunnan Province of China.
OBJECTIVES To investigate the molecular epidemiology of HIV in China's Yunnan Province, where the initial HIV-1 outbreak among injecting drug users (IDU) occurred in 1989, and to analyse the genesis and interrelationship of the epidemic with that in surrounding areas. DESIGN A molecular epidemiological investigation was conducted among IDU in three prefectures in Yunnan Province, including We...
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OBJECTIVE To examine the distribution of HIV-1 genotypes among injecting drug users (IDUs) from Dehong, Yunnan province. MATERIALS AND METHODS Blood samples from a total of 95 HIV-positive IDUs were retrospectively analyzed. Samples were collected between 2005 and 2009 from four cities in Dehong prefecture, western Yunnan province, the geographical origin of the HIV epidemic in China. HIV-1 g...
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Retroviruses are highly recombinogenic, but recombination can only occur between genomes packaged within the same virion. Until about 1994, it was generally thought that individuals do not become infected with multiple distinct HIV-1 strains, and so the possibility that recombination between divergent viruses could contribute to the evolution of HIV-1 was not widely considered. However, not lon...
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We report here three novel HIV-1 intersubtype recombinants from India. One among those is a recombinant between subtype C and CRF01_AE and another two between A1 and C. A recombinant virus with CRF01_AE is reported for the first time from India.
متن کاملMolecular Epidemiology of HIV-1 in Jilin Province, Northeastern China: Emergence of a New CRF07_BC Transmission Cluster and Intersubtype Recombinants
OBJECTIVE To investigate the HIV-1 molecular epidemiology among newly diagnosed HIV-1 infected persons living in the Jilin province of northeastern China. METHODS Plasma samples from 189 newly diagnosed HIV-1 infected patients were collected between June 2010 and August 2011 from all nine cities of Jilin province. HIV-1 nucleotide sequences of gag P17-P24 and env C2-C4 gene regions were ampli...
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ژورنال
عنوان ژورنال: Retrovirology
سال: 2015
ISSN: 1742-4690
DOI: 10.1186/s12977-015-0170-8