Functional expression and subcellular localization of an anion exchanger cloned from choroid plexus.
نویسندگان
چکیده
منابع مشابه
Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus.
We reported previously that an efficient efflux system for benzylpenicillin (PCG) is located on the choroid plexus (CP). In this study, we investigated the involvement of rat organic anion transporter 1 (rOat1; Slc22a6) and rOat3 (Slc22a8) in the uptake of PCG and p-aminohippurate (PAH) by the CP. Western blot analysis indicates the expression of rOat3, but not rOat1, on the CP, and immunohisto...
متن کاملTransepithelial organic anion transport across shark choroid plexus
Spiny dogfish shark (Squalus acanthias) lateral and IVth choroid plexuses (CP) are ultrastructurally similar to the corresponding tissues of rat. However, shark IVth CP is proportionally larger and easily accessible. Moreover, this epithelial sheet can be halved and studied in Ussing flux chambers. We have characterized transepithelial transport of the organic anions, fluorescein (FL) and 2,4-d...
متن کاملImmunohistochemical analysis of CDX2 expression in normal choroid plexus epithelium and choroid plexus tumors.
BACKGROUND The Wnt and BMP signaling pathways are involved in the morphogenesis of both gastrointestinal and choroid plexus epithelium. In the intestine, Wnt signaling represses the expression of the tumor suppressor gene CDX2 via SOX9, a transcription factor, which is also expressed in the choroid plexus. Recently, an inverse correlation between CDX2 expression and tumor grade, tumor stage and...
متن کاملTransepithelial organic anion transport by shark choroid plexus.
Spiny dogfish shark (Squalus acanthias) lateral and IV choroid plexuses (CPs) are ultrastructurally similar to the corresponding tissues of rat. However, shark IV CP is proportionally larger and easily accessible. Moreover, this epithelial sheet can be halved and studied in Ussing flux chambers. We have used confocal fluorescence microscopy and radiotracer techniques to characterize transepithe...
متن کاملI-45: Choroid Plexus Cyst
CPCs are a relatively common finding during the second trimester sonography. when a choroid plexus cyst is identified, the presence of structural malformation and other sonographic markers of aneuploidy should be assessed with a detailed fetal anatomic survey performed by an experienced person. if no other sonographic abnormalities are present, the CPC is considered isolated. given the consider...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1990
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.87.14.5278