Functional testing in animal models of spinal cord injury: not as straight forward as one would think

Functional testing in animal models of spinal cord injury: not as straight forward as one would think

When exploring potential treatments for spinal cord injury (SCI), functional recovery is deemed the most relevant outcome measure when it comes to translational considerations. Yet, assessing such recovery and potential treatment effects is challenging and the pitfalls are frequently underestimated. The consequences are that in many cases positive results cannot be reliably replicated, and like...

W5: Animal Models of Spinal Cord Injury

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w5: animal models of spinal cord injury

spinal cord injury (sci) leads to a significant health problem associated with a broad range of secondary complications and disabilities. in this regard, animal models can help us to understand the pathobiology of sci and evaluate the effects of potential treatments for sci. in contusion models of sci, different devices including surgical spring-loaded clips, balloons, forceps, weights and the ...

Animal Models in Traumatic Spinal Cord Injury

Evaluation of spinal cord injury animal models

Because there is no curative treatment for spinal cord injury, establishing an ideal animal model is important to identify injury mechanisms and develop therapies for individuals suffering from spinal cord injuries. In this article, we systematically review and analyze various kinds of animal models of spinal cord injury and assess their advantages and disadvantages for further studies.