FUNDC 1 regulates mitochondrial dynamics at the ER –mitochondrial contact site under hypoxic conditions
نویسندگان
چکیده
منابع مشابه
FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions.
In hypoxic cells, dysfunctional mitochondria are selectively removed by a specialized autophagic process called mitophagy. The ER-mitochondrial contact site (MAM) is essential for fission of mitochondria prior to engulfment, and the outer mitochondrial membrane protein FUNDC1 interacts with LC3 to recruit autophagosomes, but the mechanisms integrating these processes are poorly understood. Here...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2016
ISSN: 0261-4189,1460-2075
DOI: 10.15252/embj.201593102