FURTHER EXPERIMENTS WITH THE INTRADERMAL PNEUMOCOCCUS INFECTION IN RABBITS
نویسندگان
چکیده
منابع مشابه
Further Experiments with the Intradermal Pneumococcus Infection in Rabbits
1. The continuation of our experiments with intradermal Type I pneumococcus infection in rabbits has furnished further evidence of the marked analogies between this condition and that of human lobar pneumonia. 2. It has been found that the amount of antiserum necessary for successful therapy increases as the disease progresses, and that this progression has a definite mathematical character. Su...
متن کاملThe Evaluation of Active Resistance to Pneumococcus Infection in Rabbits
The dermal pneumococcus infection has been employed to determine the active resistance of rabbits against infection, and an evaluating scale of the gradient of resistance has been established. The significance of the various degrees of resistance has been discussed, and the possible general inferences of the findings indicated.
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The degree and duration of the active resistance against pneumococcus infection have been determined in rabbits which received intravenous injections of a heat-killed suspension of pneumococci of the three principal types. The resistance induced by the immunization procedure varied in degree and in duration with each type of Pneumococcus.
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The action of the enzyme which specifically decomposes the capsular polysaccharide of Type III Pneumococcus has been tested in Type III pneumococcus dermal infections in rabbits. When injected in sufficient amounts, this enzyme is capable of bringing about a favorable and early termination of the experimental disease which ordinarily is fatal in nearly all instances. The results of the present ...
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1. Rabbits, vaccinated by repeated intravenous injections of suspensions of heat-killed R pneumococci, acquire a marked degree of active immunity to infection with the virulent S forms of Pneumococcus Types I and II. Previously (1) it was shown that the immunization of rabbits with R cells induces active resistance to Type III infection. This immunity is effective when the infecting organisms a...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1928
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.48.3.413