G-CSF Is a Cancer Stem Cell–Specific Growth Factor—Letter
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چکیده
منابع مشابه
G-CSF Is a Cancer Stem Cell-Specific Growth Factor-Letter.
We read with interest the recent article by Agarwal and colleagues investigating the biologic significance of granulocyte colony stimulating factor (G-CSF) in stem-like subpopulations of neuroblastoma cells (1). While we find their observations provocative, and do not debate their demonstration that CD114 (the G-CSF receptor) is expressed in a rare subpopulation of neuroblastoma cells and that ...
متن کاملG-CSF Is a Cancer Stem Cell-Specific Growth Factor-Response.
We appreciate the thoughtful commentary of Maris and colleagues (1) regarding our recent publication demonstrating that G-CSF acts as a growth factor for neuroblastoma cancer stem cells (CSC) in vivo (2). In the study, both gain-of-function and loss-offunction studies confirm a significant role for G-CSF stimulating CSC-dependent xenograft growth and metastasis in experimental neuroblastoma. Ho...
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The body's immediate response to bacterial infection becomes clinically evident as an inflammatory reaction accompanied by an acute-phase response in the liver and hyperthermia. Activation of the immune system must be counterregulated to curb these processes and to prevent (or at least minimize) damage to the host tissue. The major part of this intricate regulation is performed by the cytokine ...
متن کاملStem Cell Mobilization with G-CSF versus Cyclophosphamide plus G-CSF in Mexican Children
Fifty-six aphaereses were performed in 23 pediatric patients with malignant hematological and solid tumors, following three different protocols for PBPC mobilization and distributed as follows: A: seventeen mobilized with 4 g/m(2) of cyclophosphamide (CFA) and 10 μg/kg/day of granulocyte colony stimulating factor (G-CSF), B: nineteen with CFA + G-CSF, and C: twenty only with G-CSF when the WBC ...
متن کاملCorrigendum to “Stem Cell Mobilization with G-CSF versus Cyclophosphamide plus G-CSF in Mexican Children”
[This corrects the article DOI: 10.1155/2016/4078215.].
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2015
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-15-1445