Gap junctions and ovarian folliculogenesis
نویسندگان
چکیده
منابع مشابه
Gap junctions and ovarian folliculogenesis.
Gap junctions are collections of intercellular membrane channels that allow adjacent cells to share small molecules (< 1 kDa). Gap junction channels are composed of connexins, a homologous family of more than 20 proteins. In developing follicles, gap junctions couple the growing oocyte and its surrounding follicle cells into a functional syncytium. This review summarizes evidence on the express...
متن کاملFunctional analysis of gap junctions in ovarian granulosa cells: distinct role for connexin43 in early stages of folliculogenesis.
Ovarian granulosa cells are coupled via gap junctions containing connexin43 (Cx43 or alpha-1 connexin). In the absence of Cx43, granulosa cells stop growing in an early preantral stage. However, the fact that granulosa cells of mature follicles express multiple connexins complicated interpretation of this finding. The present experiments were designed to clarify the role of Cx43 vs. these other...
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Ajacent processes on ovarian decidual cells were shown by electron microscopy to form gap junctions with one another. Micrographs of tissues preserved with lanthanum included in the fixative confirm the hexagonal array and 2-4 nm gap which characterize gap junctions. It is suggested that these gap junctions may play a role in the process of merocrine secretion from the peduncular processes of o...
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Gap junctions are sites of intercellular communication where cells are interconnected by small aqueous channels (Figure 1b). The term is morphological, for in transmission electron micrographs of thin sections, the unit membranes of the joined cells are seen to remain separated by a gap of about 2 nm (Figure 1a, inset). The gap of gap junctions distinguishes them from tight junctions, or zonula...
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In vertebrates and invertebrates, signaling among neurons is most commonly mediated by chemical synapses. At these synapses neurotransmitter released by presynaptic neurons is detected by receptors on the postsynaptic neurons, leading to an influx of ions through the receptors themselves or through channels activated by intracellular signaling downstream of the receptors. But neurons can commun...
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ژورنال
عنوان ژورنال: Reproduction
سال: 2002
ISSN: 1470-1626,1741-7899
DOI: 10.1530/reprod/123.5.613