Gating Mechanism of Hv1 Studied by Molecular Dynamic Simulations
نویسندگان
چکیده
منابع مشابه
Structural determinants of MscL gating studied by molecular dynamics simulations.
The mechanosensitive channel of large conductance (MscL) in prokaryotes plays a crucial role in exocytosis as well as in the response to osmotic downshock. The channel can be gated by tension in the membrane bilayer. The determination of functionally important residues in MscL, patch-clamp studies of pressure-conductance relationships, and the recently elucidated crystal structure of MscL from ...
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Steered molecular dynamics simulations of the mechanosensitive channel of large conductance, MscL, were used to investigate how forces arising from membrane tension induce gating of the channel. A homology model of the closed form of MscL from Escherichia coli was subjected to external forces of 35-70 pN applied to residues near the membrane-water interface. The magnitude and location of these ...
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ژورنال
عنوان ژورنال: Materials Proceedings
سال: 2020
ISSN: 2673-4605
DOI: 10.3390/iocn2020-07862