Gender Differences in Global but Not Targeted Demethylation in iPSC Reprogramming
نویسندگان
چکیده
منابع مشابه
Gender Differences in Global but Not Targeted Demethylation in iPSC Reprogramming
Global DNA demethylation is an integral part of reprogramming processes in vivo and in vitro, but whether it occurs in the derivation of induced pluripotent stem cells (iPSCs) is not known. Here, we show that iPSC reprogramming involves both global and targeted demethylation, which are separable mechanistically and by their biological outcomes. Cells at intermediate-late stages of reprogramming...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2017
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2017.01.008