Gene inactivation of a chemotaxis operon in the pathogen Leptospira interrogans
نویسندگان
چکیده
منابع مشابه
Molecular characterization of the lipL41 gene of Leptospira interrogans vaccinal serovars in Iran
Leptospirosis caused by infection with pathogenic leptospires, which is the most prevalent zoonotic disease in the world. The outer membrane proteins (OMPs) of pathogenic leptospires such as LipL41 play a crucial role in pathogenesis of this disease. Therefore a major challenge to develop an effective vaccine against leptospirosis is application of basic research on the OMPs of leptospires to i...
متن کاملComparison of Leptospira interrogans infection in the goats and sheep
Background: Most leptospiral infections in sheep and goat are asymptomatic but may result in high fever, abortion, stillbirth, agalactiae. There is a different foraging behavior between sheep and goat that may cause the different prevalence of Leptospira interrogans infection in sheep and goats. OBJECTIVES: The purpose of the present study was to compare the prevalence of L. interrogans antibod...
متن کاملA putative regulatory genetic locus modulates virulence in the pathogen Leptospira interrogans.
Limited research has been conducted on the role of transcriptional regulators in relation to virulence in Leptospira interrogans, the etiological agent of leptospirosis. Here, we identify an L. interrogans locus that encodes a sensor protein, an anti-sigma factor antagonist, and two genes encoding proteins of unknown function. Transposon insertion into the gene encoding the sensor protein led t...
متن کاملIn Vitro Identification of Novel Plasminogen-Binding Receptors of the Pathogen Leptospira interrogans
BACKGROUND Leptospirosis is a multisystem disease caused by pathogenic strains of the genus Leptospira. We have reported that Leptospira are able to bind plasminogen (PLG), to generate active plasmin in the presence of activator, and to degrade purified extracellular matrix fibronectin. METHODOLOGY/PRINCIPAL FINDINGS We have now cloned, expressed and purified 14 leptospiral recombinant protei...
متن کاملThe Leptospira interrogans lexA gene is not autoregulated.
Footprinting and mutagenesis experiments demonstrated that Leptospira interrogans LexA binds the palindrome TTTGN(5)CAAA found in the recA promoter but not in the lexA promoter. In silico analysis revealed that none of the other canonical SOS genes is under direct control of LexA, making the leptospiral lexA gene the first described which is not autoregulated.
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 2015
ISSN: 1574-6968
DOI: 10.1093/femsle/fnu054