Generation of Recombination Activating Gene-1-Deficient Neonatal Piglets: A Model of T and B Cell Deficient Severe Combined Immune Deficiency
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Generation of Recombination Activating Gene-1-Deficient Neonatal Piglets: A Model of T and B Cell Deficient Severe Combined Immune Deficiency
Although severe combined immune deficiency (SCID) is a very important research model for mice and SCID mice are widely used, there are only few reports describing the SCID pig models. Therefore, additional research in this area is needed. In this study, we describe the generation of Recombination activating gene-1 (Rag-1)-deficient neonatal piglets in Duroc breed using somatic cell nuclear tran...
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Fabio Candotti,1 Kit L. Shaw,2 Linda Muul,1 Denise Carbonaro,2 Robert Sokolic,1 Christopher Choi,2 Shepherd H. Schurman,1 Elizabeth Garabedian,1 Chimene Kesserwan,1 G. Jayashree Jagadeesh,1 Pei-Yu Fu,2 Eric Gschweng,2 Aaron Cooper,3 John F. Tisdale,4 Kenneth I. Weinberg,5 Gay M. Crooks,6 Neena Kapoor,7 Ami Shah,7 Hisham Abdel-Azim,7 Xiao-Jin Yu,7 Monika Smogorzewska,7 Alan S. Wayne,8 Howard M. ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0113833