Generic and Brand-Namel-Thyroxine Are Not Bioequivalent for Children With Severe Congenital Hypothyroidism
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چکیده
منابع مشابه
Congenital urogenital abnormalities in children with congenital hypothyroidism
Background: Congenital hypothyroidism (CH), as one of the most common congenital endocrine disorders, may be significantly associated with congenital malformations. This study investigates urogenital abnormalities in children with primary CH (PCH). Methods: This case-control study was conducted on 200 children aged three months to 1 year, referred to Amir-Kabir Hospital, Arak, Iran. One hund...
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Background: Congenital hypothyroidism is one of the most common endocrinology diseases in children. Given the importance of evaluating the normal growth and development and identifying growth and development abnormalities, this study aimed to evaluate the developmental skills of patients with congenital hypothyroidism and healthy children. Materials and Methods: This controlled cross-sectional...
متن کاملOptimisation of thyroxine dose in congenital hypothyroidism.
he introduction of the screening programme for congenital hypo-thyroidism in the late 1970s and early 1980s has been rightly hailed as a major success in the prevention of neurological handicap. With a prevalence of between 1/3000 and 1/5000 live births, congenital hypothyroidism is by far the commonest metabolic disorder leading to neurological handicap; given the inexpensive nature of assays ...
متن کاملCongenital hypothyroidism with hereditary, raised thyroxine binding globulin.
A boy with congenital hypothyroidism and hereditary raised thyroxine binding globulin is described. This hitherto unreported combination resulted in under treatment of the thyroid deficiency until serum thyroid stimulating hormone measurement became routinely available. Inadequate L-thyroxine replacement treatment between 2 and 7 years of age caused retarded bone maturation, poor growth velocit...
متن کاملdaily versus alternate day thyroxine therapy to maintain euthyroidism in children with congenital hypothyroidism
background: daily administration of thyroxine has proven efficacy in treatment of children with hypothyroidism. however, the possibility of treatment with longer dosing intervals that offers flexibility and choice in maintaining euthyroid state has not been tested in children. objectives: to study the efficacy of an alternate day regimen to maintain euthyroidism in children with congenital hypo...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2013
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2012-3125