Genetic Control of Biochemical Reactions in Neurospora

Genetic Control of Biochemical Reactions in Neurospora.

One gene, one enzyme. What a simple concept, how obvious! This fundamental relationship between gene and gene product, hinted at by several previous investigators, did not become firmly established until George W. Beadle and Edward L. Tatum performed their pioneering analyses with Neurospora crassa. Prior to their proposing the one-gene–oneenzyme hypothesis, in the early 1940s, there was little...

"Genetic Control of Biochemical Reactions in Neurospora" (1941), by George W. Beadle and Edward L. Tatum

George Wells Beadle [7] and Edward Lawrie Tatum's 1941 article "Genetic Control of Biochemical Reactions in Neurospora [8]" detailed their experiments on how genes [9] regulated chemical reactions, and how the chemical reactions in turn affected development in the organism. Beadle and Tatum experimented on Neurospora, a type of bread mold, and they concluded that mutations to genes [9] affected...

Biochemical and genetic studies on galactosamine metabolism in Neurospora crassa.

In Neurospora, galactosamine can be released from the cell wall and from an alcohol-soluble compound by acid hydrolysis. All of the detectable alcohol-soluble galactosamine was present as uridine diphospho-2-acetamido-2-deoxy-D-galactose (UDPGalNAc). The results of pulse-labeling studies and enzymatic assays indicated that UDPGalNAc was synthesized via the epimerization of uridine diphospho-2-a...

Prediction of Biochemical Reactions Using Genetic Programming

To comprehend dynamic behaviors of biological systems, many models have been proposed. These models need literatures data to represent detailed and accurate dynamics. However, those data are sufficient only in few cases. To solve this problem, many techniques have been developed, including Genetic Algorithm (GA). Those methods require defining equations before predicting biological systems. To ...

GENETICS: TATUMAND BEADLE GENETIC CONTROL OF BIOCHEMICAL REACTIONS IN NEURO- SPORA: AN "AMINOBENZOICLESS" MUTANT* By