Genetic Deletion of the A1Adenosine Receptor Limits Myocardial Ischemic Tolerance
نویسندگان
چکیده
منابع مشابه
Genetic deletion of the A1 adenosine receptor limits myocardial ischemic tolerance.
Adenosine receptors may be important determinants of intrinsic ischemic tolerance. Genetically modified mice were used to examine effects of global A1 adenosine receptor (A1AR) knockout (KO) on function and ischemic tolerance in perfused mouse hearts. Baseline contractile function and heart rate were unaltered by A1AR KO, which was shown to abolish the negative chronotropic effects of 2-chloroa...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2005
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000156075.00127.c3