Genetic engineering of negative strand RNA viruses.
نویسندگان
چکیده
منابع مشابه
Negative-strand RNA viruses: genetic engineering and applications.
The negative-strand RNA viruses are a broad group of animal viruses that comprise several important human pathogens, including influenza, measles, mumps, rabies, respiratory syncytial, Ebola, and hantaviruses. The development of new strategies to genetically manipulate the genomes of negative-strand RNA viruses has provided us with new tools to study the structure-function relationships of the ...
متن کاملGenetic manipulation of non-segmented negative-strand RNA viruses.
Negative-strand RNA viruses are a large and diverse group of enveloped viruses of both medical and economic significance. They are found in hosts from the plant and animal kingdoms, and have a wide range of morphologies, biological properties and genome organizations. A major distinction is made between viruses whose genome consists of a single RNA molecule (order Mononegavirales), including th...
متن کاملCommon mechanism for RNA encapsidation by negative-strand RNA viruses.
UNLABELLED The nucleocapsid of a negative-strand RNA virus is assembled with a single nucleocapsid protein and the viral genomic RNA. The nucleocapsid protein polymerizes along the length of the single-strand genomic RNA (viral RNA) or its cRNA. This process of encapsidation occurs concomitantly with genomic replication. Structural comparisons of several nucleocapsid-like particles show that th...
متن کاملReverse genetics of negative-strand RNA viruses: closing the circle.
The study of viruses and their interactions with host cells and organisms has benefited greatly from the ability to engineer specific mutations into viral genomes, a technique known as reverse genetics. Genome manipulations of DNA viruses, either by transfecting cells with plasmids encoding the viral genome (1) or by heterologous recombination of plasmids bearing viral sequences with the virus ...
متن کاملNucleoproteins of Negative Strand RNA Viruses; RNA Binding, Oligomerisation and Binding to Polymerase Co-Factor
Commentary on Tawar, R.G.; Duquerroy, S.; Vonrhein, C.; Varela, P.F.; Damier-Piolle, L.; Castagné, N.; MacLellan, K.; Bedouelle, H.; Bricogne, G.; Bhella, D.; Eléouët, J.-F.; Rey, F.A. Crystal structure of a nucleocapsid-like nucleoprotein-RNA complex of respiratory syncytial virus. Science2009, 326, 1279-1283.
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ژورنال
عنوان ژورنال: Uirusu
سال: 1992
ISSN: 0042-6857,1884-3433
DOI: 10.2222/jsv.42.59