Genetic influence on disease course and cytokine response in relapsing experimental allergic encephalomyelitis
نویسندگان
چکیده
منابع مشابه
Mast cells exert effects outside the central nervous system to influence experimental allergic encephalomyelitis disease course.
Previous studies using mast cell-deficient mice (W/W(v)) revealed that mast cells influence disease onset and severity of experimental allergic/autoimmune encephalomyelitis (EAE), the murine model for multiple sclerosis. The mast cell populations of these mice can be restored by transferring bone marrow-derived mast cells (BMMCs). Studies using the W/W(v) reconstitution model have lead to major...
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Multiple sclerosis is a chronic, autoimmune disease of the central nervous system, which mainly affects young women during a reproductive period of life. Since, its symptoms might be significantly affected by pregnancy, in this study we investigated the development and kinetics of disease in the model of chronic relapsing experimental autoimmune encephalomyelitis (CR-EAE), induced in geneticall...
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ژورنال
عنوان ژورنال: International Immunology
سال: 1998
ISSN: 1460-2377
DOI: 10.1093/intimm/10.3.333