Genetic testing for lung cancer risk

Risk communication in genetic testing for cancer susceptibility.

Risk communication is an integral part of genetic counseling and testing for cancer susceptibility. This paper reviews the emerging literature on this topic. Three relevant aspects of risk communication are addressed: communication of individual risk, communication of the risks inherent in genetic testing, and family communications related to risk. These studies suggest that (a) most individual...

Interest in genetic testing for modest changes in breast cancer risk: implications for SNP testing.

BACKGROUND Advances in genomics may eventually lead to 'personalized genetic medicine,' yet the clinical utility of predictive testing for modest changes in risk is unclear. We explored interest in genetic testing for genes related to modest changes in breast cancer risk in women at moderate to high risk for breast cancer. METHODS Women (n = 105) with a negative breast biopsy and ≥1 relative ...

Testing randomness for cancer risk

There are numerous stochastic models for cancer risk for a given tissue. Many rely on the following two hypotheses. 1. There is a fixed probability that a given cell division will eventually lead to a cancerous cell. 2. Cell divisions are nefarious or not independently of each other. We show that recent data on cancer risk and number of stem divisions is consistent with hypotheses 1 and 2.

translating hispanic genomic factors in lung cancer into clinical practice: egfr testing for improved outcomes

Breast Cancer Overview: Risk Factors, Screening, Genetic Testing, and Prevention

Breast cancer is the most common malignancy in women, accounting for 27% of all female cancers; it accounts for < 1% of all cancer cases in men. Breast cancer also is responsible for 15% of cancer deaths in women, making it the number-two cause of cancer death. An estimated 207,090 new breast cancer cases will be diagnosed in women and 1,970 new cases will be diagnosed in men in the United Stat...