Genetic Testing in Clinical Endocrinology

Genetic testing in clinical endocrinology.

Mendelian disease (due to disruption of a single gene) will be dealt with first as it accounts for a considerable proportion of endocrine disorders, represents the simplest and best understood instance of the contribution of genetics to endocrinology, and has given rise to routine diagnostics already available to clinicians. Complex disorders, depending on the interaction of environmental facto...

Progress in Clinical Endocrinology

in such a way as to test the hypothesis; the observations gained from the experiment are incorporated in a new hypothesis. Bernard recognized that the success or failure of the procedure was in great part dependent upon the attitude of the investigator and demanded open-mindedness, doubt, and unprejudiced observation. Today we recognize that investigation of the properties of living material ca...

Clinical Endocrinology & Metabolism

A surgically removed pituitary adenomas, approximately 30-35% appear to be silent, unassociated with clinical or biochemical evidence of any anterior pituitary hormone excess (1, 2). However, with routine immunocytochemical staining of the pituitary tumor tissue, immunoreactive hormone material can be demonstrated in a substantial number of these seemingly nonfunctioning tumors (2). Clinically ...

Clinical Endocrinology Hyperthyroidism

many as a single entity. The aetiology of the disease remains obscure. It has, however, been clearly established that thyroid-stimulating hormone (TSH) is not responsible for the excessive thyroid activity. An abnormal thyroid stimulator (known as long-acting thyroid stimulator, or LATS), which is both chemically and immunologically distinct from TSH, is found in the serum of many patients with...

Small Animal Clinical Endocrinology