Genetics, Cytogenetics, and Epigenetics of Colorectal Cancer
نویسندگان
چکیده
منابع مشابه
Genetics, Cytogenetics, and Epigenetics of Colorectal Cancer
Most of the colorectal cancer (CRC) cases are sporadic, only 25% of the patients have a family history of the disease, and major genes causing syndromes predisposing to CRC only account for 5-6% of the total cases. The following subtypes can be recognized: MIN (microsatellite instability), CIN (chromosomal instability), and CIMP (CpG island methylator phenotype). CIN occurs in 80-85% of CRC. Ch...
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Colorectal cancer (CRC) is a third most common epithelial carcinoma. CRC is known to develop from the early precancerous lesion to full blown malignancy via definite phases due to cumulative mutations and aberrant methylation of number of genes. The use of serum biomarkers that is non-invasive to discriminate cancer patients from healthy persons will prove to be an important tool to improve the...
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With deeper understanding of cell biology and genetics, it now appears that cancer is less an organ disease and more a disease of molecular mechanisms caused by mutations of specific genes. Cancer is fundamentally a disease of tissue growth regulation failure when the genes that regulate cell growth and differentiation are altered. Most cancers have multiple possible concurring causes, and it i...
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1Centro de Investigación del Cáncer, (IBMCC-CSIC/USAL) and Instituto de Investigación Biomédica de Salamanca (IBSAL), Universidad de Salamanca, 37007 Salamanca, Spain 2Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA 3Hospital Universitario de Salamanca, Paseo de San Vicente 58-182, 37007 Salamanca, Spain 4Laboratory of Molecular Bio...
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ژورنال
عنوان ژورنال: Journal of Biomedicine and Biotechnology
سال: 2011
ISSN: 1110-7243,1110-7251
DOI: 10.1155/2011/792362