Genome mapping: Utilization of molecular markers in genome mapping

Genome Mapping and Molecular Breeding of Tomato

The cultivated tomato, Lycopersicon esculentum, is the second most consumed vegetable worldwide and a well-studied crop species in terms of genetics, genomics, and breeding. It is one of the earliest crop plants for which a genetic linkage map was constructed, and currently there are several molecular maps based on crosses between the cultivated and various wild species of tomato. The high-dens...

Mapping the Cancer Genome

‘‘I f we wish to learn more about cancer, we must now concentrate on the cellular genome.” Nobel laureate Renato Dulbecco penned those words more than 20 years ago in one of the earliest public calls for what would become the Human Genome Project. “We are at a turning point,” Dulbecco, a pioneering cancer researcher, declared in 1986 in the journal Science. Discoveries in preceding years had ma...

Mapping the human genome.

Whole Genome Optical Mapping

An innovative new technology, optical mapping, is used to infer the genome map of the location of short sequence patterns called restriction sites. The technology, developed by David Schwartz, allows the visualization of the maps of randomly located single molecules around a million base pairs in length. The genome map is constructed from overlapping these shorter maps. The mathematical and com...

Comparative Genome Mapping

Some terms: Orthologous loci: loci in different species originating from the same ancestral locus paralagous loci: loci in different (or the same) species that arose due to a duplication of an ancestral locus synteny: a similar linear order of markers in two different species (or on two different linkage groups, as in soybean or Brassica) microsynteny: synteny at the sequence level, sub megase ...