Genome-wide scan reveals important additive and non-additive genetic effects associated with resistance to Haemonchus contortus in Florida Native sheep

Florida Native sheep is among the breeds best adapted to humid and hot climatic conditions such as those of Florida, USA, have shown a superior ability regulate nematode burdens. This one oldest in North America an endangered species. To ensure genetic diversity long-term survival breed, protection current stock critical conservation efforts are required promote its breeding production. The objective present study was investigate importance additive non-additive effects on resistance natural Haemonchus contortus infections using whole genome scan. A total 200 were evaluated study. Phenotypic records included faecal egg count (FEC, eggs/gram), FAMACHA® score, packed cell volume (PCV, %), body condition score average daily gain (ADG, kg). Sheep genotyped GGP Ovine 50K SNP chip 45.2 k single nucleotide polymorphism (SNP) markers spanning entire available for quality control procedures. Mixed models used analyse response variables identity by state matrix population structure. Bonferroni correction multiple testing second arbitrary threshold (0.1 × 10−3) used. Fifteen SNPs with located Ovis aries chromosome OAR1, 2, 3, 6, 8, 10, 11, 12, 13 21 associated FEC, PCV ADG. These could be potential H. exposure sheep.