Geometry sensing by self-organized protein patterns

Geometry sensing by self-organized protein patterns.

In the living cell, proteins are able to organize space much larger than their dimensions. In return, changes of intracellular space can influence biochemical reactions, allowing cells to sense their size and shape. Despite the possibility to reconstitute protein self-organization with only a few purified components, we still lack knowledge of how geometrical boundaries affect spatiotemporal pr...

Effective 2D model does not account for geometry sensing by self-organized proteins patterns.

Introduction Here we provide a thorough discussion of the model for Min protein dynamics proposed by Schweizer et al. [11]. The manuscript serves as supplementary document for our letter to the editor to appear in PNAS. Our analysis is based on the original COMSOL simulation files that were used for the publication. We show that all computational data in Schweizer et al. rely on exploitation of...

Response to Halatek and Frey: Effective two-dimensional model does account for geometry sensing by self-organized proteins patterns

The Min proteins from Escherichia coli can self-organize into traveling waves on supported lipid bilayers. In Ref. [1] we showed that these waves are guided along the boundaries of membrane patches. We introduced an effective two-dimensional model reproducing the observed patterns. In their text, Jacob Halatek and Erwin Frey contest the ability of our effective two-dimensional model to describe...

Simulating self-organized spatial patterns induced by overgrazing

Self-organized 3D-printing Patterns Simulated by Cellular Automata

3D printers are usually used for printing objects designed by 3D CAD exactly, i.e., deterministically. However, 3D printing process contains stochastic self-organization process that generate emergent patterns. A method for generating fully self-organized patterns using a fused deposition modeling (FDM) 3D printer has been developed. Melted plastic filament is extruded constantly in this method...