Germ cell tumors and associated hematologic malignancies evolve from a common shared precursor
نویسندگان
چکیده
منابع مشابه
Hematologic disorders associated with primary mediastinal nonseminomatous germ cell tumors.
BACKGROUND The association between primary germ cell tumors of the mediastinum (the space between the lung pleura that contains the heart and other chest viscera) and hematologic malignancies has been described by retrospective analysis of patients treated at individual clinical centers. To better characterize the risk of hematologic disorders in patients with extragonadal germ cell tumors and ...
متن کاملCell for Gonadal and Nongonadal Pediatric Germ Cell Tumors Multipoint Imprinting Analysis Indicates a Common Precursor
Pediatric germ cell tumors (GCTs) commonly arise at extragonadal sites. It has been proposed that nongonadal GCTs arise from ectopic primordial germ cells that have aberrantly migrated during embryogenesis. During a time between their migration and development to mature gametes, primordial germ cells are characterized by their lack of imprinting, which can be assessed by the evaluation of allel...
متن کاملMultipoint imprinting analysis indicates a common precursor cell for gonadal and nongonadal pediatric germ cell tumors.
Pediatric germ cell tumors (GCTs) commonly arise at extragonadal sites. It has been proposed that nongonadal GCTs arise from ectopic primordial germ cells that have aberrantly migrated during embryogenesis. During a time between their migration and development to mature gametes, primordial germ cells are characterized by their lack of imprinting, which can be assessed by the evaluation of allel...
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Although home care (HC) of cancer patients is a common practice, so far only limited efforts have been made to define its role in the global management of patients suffering from malignant blood disorders, who are mainly treated in hospital or in outpatient clinics. HC has not been intensively applied in the treatment of these malignancies, this approach having been traditionally reserved for t...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2020
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci139682