Global Map of SUMO Function Revealed by Protein-Protein Interaction and Genetic Networks
نویسندگان
چکیده
منابع مشابه
Global map of SUMO function revealed by protein-protein interaction and genetic networks.
Systematic functional genomics approaches were used to map a network centered on the small ubiquitin-related modifier (SUMO) system. Over 250 physical interactions were identified using the SUMO protein as bait in affinity purification-mass spectrometry and yeast two-hybrid screens. More than 500 genes and 1400 synthetic genetic interactions were mapped by synthetic genetic array (SGA) analysis...
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A. Vazquez, A. Flammini, A. Maritan and A. Vespignani 1 Department of Physics, University of Notre Dame, Notre Dame, IN 46556, USA 2 International School for Advanced Studies (SISSA) and INFM, V. Beirut 2-4, 34014 Trieste, Italy 3 The Abdus Salam International Centre for Theoretical Physics, P.O. Box 586, 34100 Trieste, Italy and 4 Laboratoire de Physique Theorique (UMR du CNRS 8627), atiment 2...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2009
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2008.12.025