Glucagon-like peptide-1 analogs against antipsychotic-induced weight gain: potential physiological benefits
نویسندگان
چکیده
منابع مشابه
Glucagon-like peptide-1 analogs against antipsychotic-induced weight gain: potential physiological benefits
BACKGROUND Antipsychotic-induced weight gain constitutes a major unresolved clinical problem which may ultimately be associated with reducing life expectancy by 25 years. Overweight is associated with brain deterioration, cognitive decline and poor quality of life, factors which are already compromised in normal weight patients with schizophrenia.Here we outline the current strategies against a...
متن کاملGlucagon Like Peptide 1 – Related Analogs
Insulin release from the beta cells is influenced by nutrients (both carbohydrates and noncarbohydrates), hormonal factors including gut hormones and neural factors. Of all these insulin secretagogues, glucose availability is the major physiological determinant of insulin secretion. The insulin secretory response is greater after oral administration of glucose than after intravenous glucose adm...
متن کاملThe therapeutic potential of glucagon-like peptide-1 analogs in the treatment of Alzheimer’s disease
Alzheimer’s disease (AD) affects more than 25% of individuals over 80 years of age and its prevalence is expected to rise with the increase of life expectancy. Existing drugs only provide symptomatic benefits but there are no currently available diseasemodifying therapies. However, evidence from preclinical studies indicates that several drugs approved for other indications could have beneficia...
متن کاملGlucagon-Like Peptide-1
Ma Glucagon-like peptide-1-(7-36) amide (GLP-1) is a human incretin hormone responsible for the release of insulin in response to food. Pre-clinical and human physiological studies have demonstrated cardioprotection from ischemia-reperfusion injury. It can reduce infarct size, ischemic left ventricular dysfunction, and myocardial stunning. GLP-1 receptor agonists have also been shown to reduce ...
متن کاملGlucagon-like peptide-1 is a physiological incretin in rat.
Glucagon-like peptide-1 7-36 amide (GLP-1) has been postulated to be the primary hormonal mediator of the entero-insular axis but evidence has been indirect. The discovery of exendin (9-39), a GLP-1 receptor antagonist, allowed this to be further investigated. The IC50 for GLP-1 receptor binding, using RIN 5AH beta-cell membranes, was found to be 0.36 nmol/l for GLP-1 and 3.44 nmol/l for exendi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Medicine
سال: 2012
ISSN: 1741-7015
DOI: 10.1186/1741-7015-10-92