Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass
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چکیده
منابع مشابه
A novel approach to increase human islet cell mass while preserving beta-cell function.
Human islet expansion in monolayer culture leads to loss of function and senescence. By maintaining the 3-D configuration of islets in fibrin gels, it is feasible to expand beta-cells in response to hepatocyte growth factor (HGF) while preserving physiologic glucose responsiveness both in vitro and in vivo after transplantation into nude mice. Islets were cultured free floating with or without ...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2010
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-010-1850-5