Glutamate measurement in Parkinson's disease using MRS at 3 T field strength
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چکیده
منابع مشابه
3-T proton MRS investigation of glutamate and glutamine in adolescents at high genetic risk for schizophrenia.
OBJECTIVE Glutamate and glutamine were examined in vivo in nonpsychotic adolescents at high genetic risk for schizophrenia by using 3-T proton magnetic resonance spectroscopy ((1)H-MRS). METHOD Spectra from the right medial frontal lobe of 20 adolescents who had a parent with schizophrenia (high-risk group; mean age=16.4 years) were compared with spectra obtained from adolescent offspring of ...
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Introduction Recent findings have revitalized the glutamate hypothesis of schizophrenia [1,2]. As improved methods for the selective determination of glutamate in brain using proton MRS emerge with increasing field strength [3,4], the role of this neurotransmitter in the schizophrenic brain in vivo during therapy can be examined more profoundly. Following the glutamate hypothesis one might expe...
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γ-Aminobutyric acid (GABA) and glutamate (Glu), major neurotransmitters in the brain, are recycled through glutamine (Gln). All three metabolites can be measured by magnetic resonance spectroscopy in vivo, although GABA measurement at 3 T requires an extra editing acquisition, such as Mescher-Garwood point-resolved spectroscopy (MEGA-PRESS). In a GABA-edited MEGA-PRESS spectrum, Glu and Gln co-...
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Introduction: It is well known that tumors have an abnormal phospolipid metabolism[1]. This is typically reflected in the higher phosphomonoester and total choline compound levels observed by in vivo P and H MRS respectively, which may be used as biomarkers for diagnosis and treatment evaluation [1,2,3,4]. For practical and sensitivity reasons H MRS has been used most extensively in the clinic ...
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R. L. O'Gorman, J. Noble, J. M. Stone, D. J. Lythgoe, M. A. McLean, F. A. Chowdhury, P. K. McGuire, M. P. Richardson, and G. J. Barker Neuroradiology, King's College Hospital, London, United Kingdom, MR-Zentrum, University Children's Hospital, Zurich, Switzerland, Medical Engineering and Physics, King's College Hospital, London, United Kingdom, Psychological Medicine and Psychiatry, Institute o...
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ژورنال
عنوان ژورنال: NMR in Biomedicine
سال: 2007
ISSN: 0952-3480,1099-1492
DOI: 10.1002/nbm.1141