Graphical models for zero-inflated single cell gene expression
نویسندگان
چکیده
منابع مشابه
Dimensionality reduction for zero-inflated single cell gene expression analysis
Single cell RNA-seq data allows insight into normal cellular function and diseases including cancer through the molecular characterisation of cellular state at the single-cell level. Dimensionality reduction of such high-dimensional datasets is essential for visualization and analysis, but single-cell RNA-seq data is challenging for classical dimensionality reduction methods because of the prev...
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هدف اصلی از این تحقیق به دست آوردن و مقایسه حق بیمه باورمندی در مدل های شمارشی گزارش نشده برای داده های طولی می باشد. در این تحقیق حق بیمه های پبش گویی بر اساس توابع ضرر مربع خطا و نمایی محاسبه شده و با هم مقایسه می شود. تمایل به گرفتن پاداش و جایزه یکی از دلایل مهم برای گزارش ندادن تصادفات می باشد و افراد برای استفاده از تخفیف اغلب از گزارش تصادفات با هزینه پائین خودداری می کنند، در این تحقیق ...
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Semicontinuous data consist of a combination of a point-mass at zero and a positive skewed distribution. This type of non-negative data distribution is found in data from many fields, but presents unique challenges for analysis. Specifically, these data cannot be analyzed using positive distributions, but distributions that are unbounded are also likely a poor fit. Two-part models incorporate b...
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Applications of zero-inflated count data models have proliferated in health economics. However, zero-inflated Poisson or zero-inflated negative binomial maximum likelihood estimators are not robust to misspecification. This article proposes Poisson quasi-likelihood estimators as an alternative. These estimators are consistent in the presence of excess zeros without having to specify the full di...
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SUMMARY In psychosocial and behavioral studies count outcomes recording the frequencies of the occurrence of some health or behavior outcomes (such as the number of unprotected sexual behaviors during a period of time) often contain a preponderance of zeroes because of the presence of 'structural zeroes' that occur when some subjects are not at risk for the behavior of interest. Unlike random z...
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ژورنال
عنوان ژورنال: The Annals of Applied Statistics
سال: 2019
ISSN: 1932-6157
DOI: 10.1214/18-aoas1213