Green synthesized selenium nanoparticles using Spermacoce hispida as carrier of s-allyl glutathione: to accomplish hepatoprotective and nephroprotective activity against acetaminophen toxicity
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چکیده
منابع مشابه
Antioxidant properties and Glutathione S-transferases inhibitory activity of Alchornea cordifolia leaf extract in Acetaminophen toxicity
Paracetamol (acetaminophen, PCM) is a widely used over-the-counter analgesic and antipyretic drug. Intake of a large dose of PCM may result in severe hepatic necrosis. Oxidative stress is mediated by oxidative capacities of the PCM metabolite (N-acetyl-para-benzo quinoneimine, NAPQI), which covalently binds to proteins and other macromolecules to cause cellular damage. At low doses, NAPQI is ...
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Aim: To evaluate the analgesic activity of aqueous extract of S. hispida on thermal and chemical method induced pain in mice. Materials and methods: 48 Adult albino mice (Swiss strain) weighing 25-30 gm were selected. 24 animals were allocated to each experimental model, in each model there were 4 groups. The control group received vehicle (10 ml /kg, p.o), standard group aspirin (300 mg /kg, p...
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Silver nanoparticles (AgNPs) have attracted the most interest in terms of their potential biomedical and industrial applications. However, these nanoparticles have shown their toxic behavior toward environment, living tissues, and organisms. Selenium (Se), an essential trace element, is necessary for various metabolic processes, including protection against oxidative stress and immune function....
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Punica granatum leaf extracts have been used since time immemorial in traditional medicines. It is used for its antioxidant properties. Green nanoparticle synthesis is an emerging field which has opened an entirely different scope for medicinal formulations. It has been reported by many users that the green nanoparticles are more effective medicines as compared with their simple extracts. Thus,...
متن کاملantioxidant properties and glutathione s-transferases inhibitory activity of alchornea cordifolia leaf extract in acetaminophen toxicity
paracetamol (acetaminophen, pcm) is a widely used over-the-counter analgesic and antipyretic drug. intake of a large dose of pcm may result in severe hepatic necrosis. oxidative stress is mediated by oxidative capacities of the pcm metabolite (n-acetyl-para-benzo quinoneimine, napqi), which covalently binds to proteins and other macromolecules to cause cellular damage. at low doses, napqi is co...
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ژورنال
عنوان ژورنال: Artificial Cells, Nanomedicine, and Biotechnology
سال: 2019
ISSN: 2169-1401,2169-141X
DOI: 10.1080/21691401.2018.1543192